Does Codeine Show Up on a 12-Panel Drug Test?
Evidence-based answer reviewed against SAMHSA cutoffs and FDA assay documentation · Updated August 2026
Quick answer: Yes. A 12-panel drug test includes Codeine (screened around Covered by the standard opiate strip: 2,000 ng/mL morphine/codeine.).
What a 12-panel drug test actually tests for
Here's the full drug list with typical urine cutoffs:
| Drug class | Typical urine cutoff |
|---|---|
| 10-panel list | above |
| Oxycodone | 100 |
| Buprenorphine (buprenorphine) | ~5–10 |
| Fentanyl OR Ecstasy-slot variant | 1+ / config |
| Codeine | ✅ Detected |
Who uses this panel
Today's most common expanded cup for pain clinics, MAT programs, corrections and cautious employers.
What candidates should know
Lean's codeine lands squarely on the classic opiate panel — this is one street drug standard testing catches without any expansion.
Promethazine itself isn't screened, but it can flag old-generation amphetamine screens as a false positive; confirmation sorts it out.
Prescription codeine (codeine-acetaminophen tablets, cough syrup) verifies via MRO like any opioid script.
Not on this panel? Read this
Absence from a panel means absence of testing — not safety. Specialty orders, expanded cups, probation panels and sports programs reach further. If your situation involves court supervision, treatment programs or safety-sensitive certification, assume wider coverage.
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Does Promethazine Show up on a Drug Test?
Yes — Codeine appears on standard drug panels. Full guide →
Can Codeine Cause a False Positive Drug Test?
Can Codeine trigger a false positive? Cross-reactivity evidence, confirmation testing, and how to clear your name with the MRO. Full guide →
How Long Does Codeine Show up in a Drug Test?
How long Codeine stays detectable in your system (all test types) — urine, hair, saliva & blood windows explained with cutoffs. Full guide →
How Long Does Codeine Stay in Urine Drug Test?
How long Codeine stays detectable in urine — urine, hair, saliva & blood windows explained with cutoffs. Full guide →
Does Promethazine Show up on a 12 Panel Drug Test?
Yes — Codeine sits on standard 5/10/12-panel screens. Prescription? Declare it for MRO verification.
Do prescriptions count against me?
No — verified prescriptions report as negative through the Medical Review Officer. Declare medications at collection and answer the follow-up call.
Sources & further reading
- SAMHSA — Mandatory Guidelines for Federal Workplace Drug Testing Programs (cutoffs, MRO process)
- DOT — 49 CFR Part 40 procedures for transportation workplace testing
- Brahm NC et al., Mayo Clinic Proceedings 2008;83(1):66–76 — false-positive cross-reactivity reference
- FDA — drug-of-abuse test device labeling (detection window conventions)