Does Hydrocodone Show Up on a 10-Panel Drug Test?
Evidence-based answer reviewed against SAMHSA cutoffs and FDA assay documentation · Updated August 2026
Quick answer: Yes. A 10-panel drug test includes Hydrocodone (screened around Detected on semi-synthetic opiate slots (typically 100 ng/mL hydromorphone/hydrocodone family) on expanded panels.).
What a 10-panel drug test actually tests for
Here's the full drug list with typical urine cutoffs:
| Drug class | Typical urine cutoff |
|---|---|
| THC | 50 / 15 |
| Cocaine | 150 / 100 |
| Opiates incl. heroin | 2000 / 2000 |
| Amphetamines | 500 / 250 |
| PCP | 25 / 25 |
| Barbiturates | ~250–300 |
| Benzodiazepines | ~300 / 200 |
| Methadone | ~300 / EDDP |
| MDMA | 500 / 250 |
| Propoxyphene/propoxyphene (legacy) | ~300 |
| Hydrocodone | ✅ Detected |
Who uses this panel
The default 'general workforce' panel for many non-DOT employers — everything DOT tests plus depressants and ecstasy.
What candidates should know
hydrocodone-acetaminophen tablets/hydrocodone-acetaminophen tablets combine hydrocodone with acetaminophen. Hydrocodone partially registers on broad opiate assays (it metabolizes to hydromorphone, which cross-reacts), but dedicated semi-synthetic strips on 10/12-panel cups catch it reliably.
Prescriptions verify through the MRO process identically to other opioids.
Not on this panel? Read this
Absence from a panel means absence of testing — not safety. Specialty orders, expanded cups, probation panels and sports programs reach further. If your situation involves court supervision, treatment programs or safety-sensitive certification, assume wider coverage.
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Does Hydrocodone Show up Drug Test?
Yes — Hydrocodone appears on standard drug panels. Full guide →
How Long Does Hydrocodone Stay in Your System Drug Test?
How long Hydrocodone stays detectable in your system (all test types) — urine, hair, saliva & blood windows explained with cutoffs. Full guide →
How Long Does Hydrocodone Stay in Urine Drug Test?
How long Hydrocodone stays detectable in urine — urine, hair, saliva & blood windows explained with cutoffs. Full guide →
Can Hydrocodone Cause a False Positive Drug Test?
Can Hydrocodone trigger a false positive? Cross-reactivity evidence, confirmation testing, and how to clear your name with the MRO. Full guide →
Does Hydrocodone Show up on a 10 Panel Drug Test?
No — standard employment panels don't include Hydrocodone. Only specialized orders reach it.
Do prescriptions count against me?
No — verified prescriptions report as negative through the Medical Review Officer. Declare medications at collection and answer the follow-up call.
Sources & further reading
- SAMHSA — Mandatory Guidelines for Federal Workplace Drug Testing Programs (cutoffs, MRO process)
- DOT — 49 CFR Part 40 procedures for transportation workplace testing
- Brahm NC et al., Mayo Clinic Proceedings 2008;83(1):66–76 — false-positive cross-reactivity reference
- FDA — drug-of-abuse test device labeling (detection window conventions)