Does Oxycodone Show Up on a 5-Panel Drug Test?
Evidence-based answer reviewed against SAMHSA cutoffs and FDA assay documentation · Updated August 2026
Quick answer: No. Standard 5-panel cups do not test for Oxycodone. Benzos, MDMA, methadone, oxycodone, buprenorphine, fentanyl, barbiturates, kratom, shrooms, LSD.
What a 5-panel drug test actually tests for
Here's the full drug list with typical urine cutoffs:
| Drug class | Typical urine cutoff |
|---|---|
| THC (marijuana) | 50 ng/mL urine initial / 15 confirm |
| Cocaine (benzoylecgonine) | 150 / 100 ng/mL |
| Opiates (morphine, codeine, 6-MAM heroin marker) | 2,000 / 2,000 ng/mL |
| Amphetamines (mixed amphetamine salts class) | 500 / 250 ng/mL |
| PCP | 25 / 25 ng/mL |
| Oxycodone | ❌ Not detected |
Who uses this panel
The federal standard since the Reagan era — still the DOT-mandated panel for CDL drivers, aviation, maritime and other safety-sensitive work.
What candidates should know
oxycodone-acetaminophen tablets contains oxycodone plus acetaminophen; the acetaminophen is irrelevant to testing. Oxycodone needs its own assay slot — legacy 5-panel opiate tests (morphine/codeine-focused at 2,000 ng/mL) often miss it, which is why 10/12-panel cups add an OXY strip.
A valid prescription verifies as negative through the MRO; keep the bottle or pharmacy record handy during hiring screenings.
Extended-release formulations (extended-release oxycodone) linger marginally longer than instant-release oxycodone-acetaminophen tablets.
Not on this panel? Read this
Absence from a panel means absence of testing — not safety. Specialty orders, expanded cups, probation panels and sports programs reach further. If your situation involves court supervision, treatment programs or safety-sensitive certification, assume wider coverage.
Certified labs nationwide · Results in 1–2 days
Need a test? Order online, test same-day →People also ask
Does Oxycodone Show up on a Drug Test?
No — Oxycodone is absent from standard drug panels. Full guide →
How Long Does oxycodone-acetaminophen tablets Stay in Your System Drug Test?
How long Oxycodone stays detectable in your system (all test types) — urine, hair, saliva & blood windows explained with cutoffs. Full guide →
How to Pass a Drug Test for oxycodone-acetaminophen tablets?
Evidence-based ways to pass a drug test for Oxycodone — realistic timelines, what works, what backfires, and dilution flags to avoid. Full guide →
How Long Does Oxycodone Stay in Urine Drug Test?
How long Oxycodone stays detectable in urine — urine, hair, saliva & blood windows explained with cutoffs. Full guide →
Does Oxycodone Show up in a 5 Panel Drug Test?
No — standard employment panels don't include Oxycodone. Only specialized orders reach it.
Does Oxycodone Show up on a 5 Panel Drug Test?
No — standard employment panels don't include Oxycodone. Only specialized orders reach it.
Do prescriptions count against me?
No — verified prescriptions report as negative through the Medical Review Officer. Declare medications at collection and answer the follow-up call.
Sources & further reading
- SAMHSA — Mandatory Guidelines for Federal Workplace Drug Testing Programs (cutoffs, MRO process)
- DOT — 49 CFR Part 40 procedures for transportation workplace testing
- Brahm NC et al., Mayo Clinic Proceedings 2008;83(1):66–76 — false-positive cross-reactivity reference
- FDA — drug-of-abuse test device labeling (detection window conventions)