What Is Oxycodone? Drug Class, Schedule & Drug Test Answers
Evidence-based answer reviewed against SAMHSA cutoffs and FDA assay documentation · Updated September 2026
Quick answer: Oxycodone is a Semi-synthetic opioid agonist. Schedule II by prescription. Here's how the drug is classified, whether it's a narcotic/controlled substance, and what that means for testing.
What is Oxycodone?
Drug class: Semi-synthetic opioid agonist
Federal schedule: Schedule II by prescription.
oxycodone-acetaminophen tablets contains oxycodone plus acetaminophen; the acetaminophen is irrelevant to testing. Oxycodone needs its own assay slot — legacy 5-panel opiate tests (morphine/codeine-focused at 2,000 ng/mL) often miss it, which is why 10/12-panel cups add an OXY strip.
Is Oxycodone a narcotic?
It is classified as a narcotic under the DEA's federal schedule. What matters more for you: Schedule II by prescription..
Does it show up on drug tests?
No — it is not on the standard 5-panel; it appears only on expanded or panel-specific orders. See the full Oxycodone drug test guide for detection windows and cutoffs.
False-positive caution
- No significant oxycodone false positives documented on modern assays; poppy seeds affect morphine/codeine results, not oxycodone strips.
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Does Oxycodone Show up on a Drug Test?
No — Oxycodone is absent from standard drug panels. Full guide →
How Long Does oxycodone-acetaminophen tablets Stay in Your System Drug Test?
How long Oxycodone stays detectable in your system (all test types) — urine, hair, saliva & blood windows explained with cutoffs. Full guide →
How to Pass a Drug Test for oxycodone-acetaminophen tablets?
Evidence-based ways to pass a drug test for Oxycodone — realistic timelines, what works, what backfires, and dilution flags to avoid. Full guide →
How Long Does Oxycodone Stay in Urine Drug Test?
How long Oxycodone stays detectable in urine — urine, hair, saliva & blood windows explained with cutoffs. Full guide →
Do prescriptions count against me?
No — verified prescriptions report as negative through the Medical Review Officer. Declare medications at collection and answer the follow-up call.
Sources & further reading
- SAMHSA — Mandatory Guidelines for Federal Workplace Drug Testing Programs (cutoffs, MRO process)
- DOT — 49 CFR Part 40 procedures for transportation workplace testing
- Brahm NC et al., Mayo Clinic Proceedings 2008;83(1):66–76 — false-positive cross-reactivity reference
- FDA — drug-of-abuse test device labeling (detection window conventions)