Quick answer
Trazodone is typically detectable in urine for screen interference window ~2–4 days post-dose after any use. It is screened on standard 5-panel, 10-panel, 12-panel, DOT drug tests.
Screened on: 5-panel 10-panel 12-panel DOT
Typical cutoff: Not directly screened; cross-reacts on some amphetamine immunoassays.
Detection window by test type
| urine | |
|---|---|
| Any use | screen interference window ~2–4 days post-dose |
| saliva | |
| Any use | n/a (indirect) |
| hair | |
| Any use | n/a |
| blood | |
| Any use | n/a |
Ranges reflect typical published detection windows and vary with dose, frequency, body composition, hydration and the assay used.
Key details
Trazodone doesn't get tested FOR — it can cause amphetamine-strip screen positives in documented case reports. Confirmation testing (GC–MS) shows no amphetamine and closes the loop.
If you take Desyrel nightly and receive an unexpected amphetamine screen flag, invoke the MRO review immediately and list trazodone.
False positives & cross-reactivity
- Amphetamine-screen false positives: case-documented (Francisco & Mehta; Roberge reports).
Frequently asked questions
How long does trazodone stay in your system?
In urine, typical detection is screen interference window ~2–4 days post-dose (any use). Hair can detect use for up to 90 days and saliva/blood windows are usually shorter.
Will trazodone show up on a standard drug test?
Yes — Trazodone is screened on standard panels (5-panel, 10-panel, 12-panel, DOT).
Can anything cause a false positive for trazodone?
Amphetamine-screen false positives: case-documented (Francisco & Mehta; Roberge reports).
How accurate are these detection windows?
They are typical ranges from published literature and assay documentation, not guarantees. Clearance depends on dose, frequency, metabolism and the specific test cutoff used.
Related substances
Cite this page
DrugPanels. “Trazodone Detection Time.” https://drugpanels.com/detection/trazodone/. Accessed 2026-09-10.
Sources
- Brahm NC et al., Commonly prescribed medications and potential false-positive drug test results, Mayo Clinic Proceedings 2008 — Mayo Clinic Proceedings — pubmed.ncbi.nlm.nih.gov
- Peer-reviewed literature (PubMed) — U.S. National Library of Medicine — pubmed.ncbi.nlm.nih.gov
Detection windows describe typical ranges from the published literature and assay documentation; individual results vary. See our methodology.