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Substances
Adderall / amphetaminesStimulant (amphetamine / dextroamphetamine / lisdexamfetamine)AlcoholCentral nervous system depressant (ethanol)Ambien (zolpidem)Z-drug hypnotic (GABA-A alpha-1 selective)Anabolic steroidsAnabolic-androgenic steroid hormonesAshwagandhaAdaptogenic herb supplementBaclofenGABA-B agonist muscle relaxantBarbituratesDepressant (GABA-A prolonger)Benadryl / NyQuil (diphenhydramine & doxylamine)First-generation antihistaminesBenzodiazepines (Xanax, Valium, Klonopin, Ativan)Depressant (GABA-A modulator)Buspirone (BusPar)Azapirone anxiolyticCBD (cannabidiol)Non-intoxicating cannabinoidClonidineCentral alpha-2 agonistCoca (leaf and tea)Plant source of cocaine (Erythroxylum coca)CocaineStimulant (benzoylmethylecgonine)Codeine / promethazine ('lean')Opioid (codeine) + sedating antihistamine (promethazine)CreatineErgogenic amino-acid derivative supplementDMTTryptamine psychedelicDelta-10 THCCannabinoid (minor hemp-derived THC isomer)Delta-8 THCCannabinoid (hemp-derived psychoactive isomer of THC)Dilaudid (hydromorphone)Semi-synthetic opioid agonistEscitalopram (Lexapro)SSRI antidepressantFentanylSynthetic ultra-potent opioidFluoxetine (Prozac)SSRI antidepressantGabapentin (Neurontin)Anticonvulsant/gabapentinoidHempCannabis variant (≤0.3% delta-9 THC by dry weight)Hydrocodone (Norco, Vicodin)Semi-synthetic opioid agonistHydroxyzine (Atarax/Vistaril)First-gen antihistamine anxiolyticK2 / Spice (synthetic cannabinoids)Full cannabinoid-receptor agonists (indazole/indole families)KavaKavalactone anxiolytic botanicalKetamineDissociative anesthetic (NMDA antagonist)Kratom (mitragynine)Opioid-receptor-active plant alkaloidLSD (acid)Psychedelic ergolineLidocaineAmide local anestheticMDMA (ecstasy/molly)Entactogen stimulantMelatoninEndogenous hormone supplementMethadoneFull synthetic opioid agonist (MAT)MethamphetamineStimulant (N-methylamphetamine)MethylphenidatePiperidine-based central stimulantModafinilAtypical wakefulness-promoting agentMorphineNatural opioid agonistMuscle relaxers (Flexeril, Soma, tizanidine)Centrally acting skeletal muscle relaxantsNSAIDs (ibuprofen, naproxen, ketorolac)Non-steroidal anti-inflammatory analgesicsNaltrexoneOpioid antagonistNicotine (smoking/vaping/Zyn)Stimulant alkaloidNyQuil & cold medicinesCombination OTC (antihistamine ± DXM ± alcohol)Ondansetron5-HT3 antiemeticOpiates / opioids (heroin, morphine, codeine)Natural and semi-synthetic opioid agonistsOpiumOpiate (dried latex of the opium poppy, containing morphine and codeine)Oxycodone (Percocet, OxyContin)Semi-synthetic opioid agonistOzempic / GLP-1 (semaglutide)GLP-1 receptor agonist peptidePCP (angel dust)Dissociative anestheticPeptides (BPC-157, ipamorelin)Signaling peptide research compoundsPhentermine (Adipex-P)Sympathomimetic amine appetite suppressantPoppers (alkyl nitrites)Volatile nitritesPregabalin (Lyrica)Anticonvulsant/gabapentinoidPsilocybin mushrooms ('shrooms')Psychedelic tryptamine (psilocybin → psilocin)Quetiapine (Seroquel)Atypical antipsychoticSalvia divinorumKappa-opioid agonist hallucinogenSertraline (Zoloft)SSRI antidepressantSildenafilPDE-5 inhibitorSuboxone (buprenorphine)Partial opioid agonist (opioid-use-disorder treatment)Sudafed (pseudoephedrine)Sympathomimetic decongestantTramadol (Ultram)Atypical synthetic opioid + SNRI activityTrazodoneSARI antidepressantWeed / THC (cannabis)Cannabinoid (psychoactive compound: delta-9-tetrahydrocannabinol)Wellbutrin (bupropion)NDRI antidepressant / smoking-cessation aidWild lettuce (lactucarium)Sedative botanical lactones