Does Trazodone Show Up on a Drug Test?
Evidence-based answer reviewed against SAMHSA cutoffs and FDA assay documentation · Updated August 2026
Quick answer: Sometimes. Trazodone isn't on every standard panel — coverage depends on panel width and assay configuration. Not directly screened; cross-reacts on some amphetamine immunoassays.
Which panels screen for it
| Panel | Trazodone status |
|---|---|
| 5-Panel | ⚠️ Screen interference only |
| 10-Panel | ⚠️ Screen interference only |
| 12-Panel | ⚠️ Screen interference only |
| DOT 5-panel (safety-sensitive) | confirmation resolves |
The details that matter
Trazodone doesn't get tested FOR — it can cause amphetamine-strip screen positives in documented case reports. Confirmation testing (GC–MS) shows no amphetamine and closes the loop.
If you take trazodone nightly and receive an unexpected amphetamine screen flag, invoke the MRO review immediately and list trazodone.
If it IS detected, how long does it last?
| Test type | Typical Trazodone detection window |
|---|---|
| Urine | any: screen interference window ~2–4 days post-dose |
| Saliva (Mouth Swab) | any: n/a (indirect) |
| Hair Follicles | n/a |
| Blood | any: n/a |
False-positive notes
- Amphetamine-screen false positives: case-documented (Francisco & Mehta; Roberge reports).
Remember: immunoassay screens produce artifacts; mass-spec confirmation and the MRO review are where legitimate explanations win.
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Does Trazodone Show up on Drug Test?
No — standard employment panels don't include Trazodone. Only specialized orders reach it.
Will Trazodone Show up in a Drug Test?
No — standard employment panels don't include Trazodone. Only specialized orders reach it.
How accurate are drug tests?
Lab-based immunoassay screens agree with confirmation testing ~97% of the time; confirmed GC–MS results are considered definitive. Home kits trade legal defensibility for convenience.
Do prescriptions count against me?
No — verified prescriptions report as negative through the Medical Review Officer. Declare medications at collection and answer the follow-up call.
Sources & further reading
- SAMHSA — Mandatory Guidelines for Federal Workplace Drug Testing Programs (cutoffs, MRO process)
- DOT — 49 CFR Part 40 procedures for transportation workplace testing
- Brahm NC et al., Mayo Clinic Proceedings 2008;83(1):66–76 — false-positive cross-reactivity reference
- FDA — drug-of-abuse test device labeling (detection window conventions)